The shots didn't effect me too much. I took them once daily and though the bottle warned of headache and dizziness, I did not feel that. However, now that I have been taking the twice daily Estrace (estrogen), I cannot stop my tears. I cry and feel overwhelmed about everything. My poor hubsy is at odds. He tries his best to keep me calm, but really, how can you calm an irrational drama queen hyped up on estrogen?! He's a trooper though. He is going to stick by me through this all, and is really really proud that I am able to do this for someone else.